Ontology highlight
ABSTRACT:
SUBMITTER: Takeuchi S
PROVIDER: S-EPMC6066645 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Takeuchi Shigeko S Tooyama Ikuo I
Acta histochemica et cytochemica 20180523 3
The TRK-fused gene (<i>TFG</i>) is reported to be involved in the regulation of cell size, apoptosis, cell growth, ER-Golgi protein secretion, NF-κβ pathway signaling, the ubiquitin-proteasome system, and pancreatic β-cell mass and function. <i>TFG</i> mutations were reported in some neurodegenerative diseases affecting sensory and motor functions. However, the function of <i>TFG</i> in the nervous system and how <i>TFG</i> mutations lead to neurodegeneration remain unclear. In this study, we em ...[more]