Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC6067963 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Lu Yanxin Y Liu Yang Y Pang Ying Y Pacak Karel K Yang Chunzhang C
Pharmacology & therapeutics 20180403
DNA repair pathways are evolutionarily conserved molecular mechanisms that maintain the integrity of genomic DNA. In cancer therapies, the integrity and activity of DNA repair pathways predict therapy resistance and disease outcome. Members of the poly (ADP-ribose) polymerase (PARP) family initiate and organize the biologic process of DNA repair, which counteracts many types of chemotherapies. Since the first development in approximately 3 decades ago, PARP inhibitors have greatly changed the co ...[more]