Ontology highlight
ABSTRACT:
SUBMITTER: Persi E
PROVIDER: S-EPMC6068141 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Persi Erez E Duran-Frigola Miquel M Damaghi Mehdi M Roush William R WR Aloy Patrick P Cleveland John L JL Gillies Robert J RJ Ruppin Eytan E
Nature communications 20180731 1
A reverse pH gradient is a hallmark of cancer metabolism, manifested by extracellular acidosis and intracellular alkalization. While consequences of extracellular acidosis are known, the roles of intracellular alkalization are incompletely understood. By reconstructing and integrating enzymatic pH-dependent activity profiles into cell-specific genome-scale metabolic models, we develop a computational methodology that explores how intracellular pH (pHi) can modulate metabolism. We show that in si ...[more]