High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis.
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ABSTRACT:
SUBMITTER: Ghaly S
PROVIDER: S-EPMC6068189 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
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High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis.
Ghaly Simon S Kaakoush Nadeem O NO Lloyd Frances F McGonigle Terence T Mok Danny D Baird Angela A Klopcic Borut B Gordon Lavinia L Gorman Shelley S Forest Cynthia C Bouillon Roger R Lawrance Ian C IC Hart Prue H PH
Scientific reports 20180731 1
Vitamin D has been suggested as a possible adjunctive treatment to ameliorate disease severity in human inflammatory bowel disease. In this study, the effects of diets containing high (D++, 10,000 IU/kg), moderate (D+, 2,280 IU/kg) or no vitamin D (D-) on the severity of dextran sodium sulphate (DSS) colitis in female C57Bl/6 mice were investigated. The group on high dose vitamin D (D++) developed the most severe colitis as measured by blinded endoscopic (p < 0.001) and histologic (p < 0.05) ass ...[more]
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2023-11-20 | GSE247865 | GEO