Ontology highlight
ABSTRACT:
SUBMITTER: Melagraki G
PROVIDER: S-EPMC6068282 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Melagraki Georgia G Ntougkos Evangelos E Papadopoulou Dimitra D Rinotas Vagelis V Leonis Georgios G Douni Eleni E Afantitis Antreas A Kollias George G
Frontiers in pharmacology 20180725
An <i>in silico</i> drug discovery pipeline for the virtual screening of plant-origin natural products (NPs) was developed to explore new direct inhibitors of TNF and its close relative receptor activator of nuclear factor kappa-B ligand (RANKL), both representing attractive therapeutic targets for many chronic inflammatory conditions. Direct TNF inhibition through identification of potent small molecules is a highly desired goal; however, it is often hampered by severe limitations. Our approach ...[more]