Ontology highlight
ABSTRACT:
SUBMITTER: Serrano-Candelas E
PROVIDER: S-EPMC6068349 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Serrano-Candelas Eva E Ainsua-Enrich Erola E Navinés-Ferrer Arnau A Rodrigues Paulo P García-Valverde Alfonso A Bazzocco Sarah S Macaya Irati I Arribas Joaquín J Serrano César C Sayós Joan J Arango Diego D Martin Margarita M
Molecular oncology 20180630 8
Gastrointestinal stromal tumors (GISTs) represent about 80% of the mesenchymal neoplasms of the gastrointestinal tract. Most GISTs contain oncogenic KIT (85%) or PDGFRA (5%) receptors. The kinase inhibitor imatinib mesylate is the preferential treatment for these tumors; however, the development of drug resistance has highlighted the need for novel therapeutic strategies. Recently, we reported that the adaptor molecule SH3 Binding Protein 2 (SH3BP2) regulates KIT expression and signaling in huma ...[more]