Ontology highlight
ABSTRACT:
SUBMITTER: Ogawa S
PROVIDER: S-EPMC6068461 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Ogawa Shiho S Kido Sayuri S Handa Tetsuya T Ogawa Hidesato H Asakawa Haruhiko H Takahashi Tatsuro S TS Nakagawa Takuro T Hiraoka Yasushi Y Masukata Hisao H
The EMBO journal 20180711 15
DNA replication initiates at many discrete loci on eukaryotic chromosomes, and individual replication origins are regulated under a spatiotemporal program. However, the underlying mechanisms of this regulation remain largely unknown. In the fission yeast <i>Schizosaccharomyces pombe</i>, the telomere-binding protein Taz1, ortholog of human TRF1/TRF2, regulates a subset of late replication origins by binding to the telomere-like sequence near the origins. Here, we showed using a <i>lacO</i>/LacI- ...[more]