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Analysis and Isolation of Potential Artemisinin Precursors from Waste Streams of Artemisia Annua Extraction.


ABSTRACT: High-performance liquid chromatography, liquid chromatography-mass spectrometry, and gas chromatography-mass spectrometry methods were developed to analyze the process waste streams of Artemisia Annua extraction. Results from these methods suggested that the final waste from the extraction process could serve as a source of dihydroartemisinic acid (DHAA) that could be converted to additional artemisinin. Two additional impurities were isolated and identified in the waste material as well as in A. annua leaf samples. That these impurities also appear as side-products in chemical transformations of DHAA to artemisinin supports the conclusion that the in vivo transformation proceeds as nonspecific oxidations. These impurities do not appear in isolated artemisinin. A simple, high-yielding procedure for recovery of DHAA from the primary waste stream was developed.

SUBMITTER: Stringham RW 

PROVIDER: S-EPMC6068693 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Analysis and Isolation of Potential Artemisinin Precursors from Waste Streams of <i>Artemisia Annua</i> Extraction.

Stringham Rodger W RW   Moore Gary L GL   Teager David S DS   Yue Tai-Yuen TY  

ACS omega 20180712 7


High-performance liquid chromatography, liquid chromatography-mass spectrometry, and gas chromatography-mass spectrometry methods were developed to analyze the process waste streams of <i>Artemisia Annua</i> extraction. Results from these methods suggested that the final waste from the extraction process could serve as a source of dihydroartemisinic acid (DHAA) that could be converted to additional artemisinin. Two additional impurities were isolated and identified in the waste material as well  ...[more]

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