CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sites.

ABSTRACT:

Background

Recent technological advances have delivered the genome-wide targets of many important transcription factors (TFs). However, increasing evidence suggests that not all target sites mediate regulatory function, raising the questions of how to determine which sites are active, what are the epigenetic consequences of TF binding at these sites, and how the specificity is coded. To address these questions, we focused on CRX, a disease-associated homeodomain TF required for photoreceptor gene expression and development. Since CRX binds more than 6000 sites across the genome in the retina, we profiled chromatin landscape changes at each binding site during normal development and in the absence of CRX and interpreted the results by thorough investigation of other epigenomic datas

SUBMITTER: Ruzycki PA 

PROVIDER: S-EPMC6069558 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature