Ontology highlight
ABSTRACT:
SUBMITTER: Engel M
PROVIDER: S-EPMC6069762 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Engel Mareen M Eggert Carola C Kaplick Paul M PM Eder Matthias M Röh Simone S Tietze Lisa L Namendorf Christian C Arloth Janine J Weber Peter P Rex-Haffner Monika M Geula Shay S Jakovcevski Mira M Hanna Jacob H JH Leshkowitz Dena D Uhr Manfred M Wotjak Carsten T CT Schmidt Mathias V MV Deussing Jan M JM Binder Elisabeth B EB Chen Alon A
Neuron 20180701 2
N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) and N<sup>6</sup>,2'-O-dimethyladenosine (m<sup>6</sup>Am) are abundant mRNA modifications that regulate transcript processing and translation. The role of both, here termed m<sup>6</sup>A/m, in the stress response in the adult brain in vivo is currently unknown. Here, we provide a detailed analysis of the stress epitranscriptome using m<sup>6</sup>A/m-seq, global and gene-specific m<sup>6</sup>A/m measurements. We show that stress exposure and gluc ...[more]