Ontology highlight
ABSTRACT:
SUBMITTER: Tang C
PROVIDER: S-EPMC6070003 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Tang Chengyuan C Han Hailong H Yan Mingjuan M Zhu Shiyao S Liu Jing J Liu Zhiwen Z He Liyu L Tan Jieqiong J Liu Yu Y Liu Hong H Sun Lin L Duan Shaobin S Peng Youming Y Liu Fuyou F Yin Xiao-Ming XM Zhang Zhuohua Z Dong Zheng Z
Autophagy 20180217 5
Damaged or dysfunctional mitochondria are toxic to the cell by producing reactive oxygen species and releasing cell death factors. Therefore, timely removal of these organelles is critical to cellular homeostasis and viability. Mitophagy is the mechanism of selective degradation of mitochondria via autophagy. The significance of mitophagy in kidney diseases, including ischemic acute kidney injury (AKI), has yet to be established, and the involved pathway of mitophagy remains poorly understood. H ...[more]