Ontology highlight
ABSTRACT:
SUBMITTER: Chen-Roetling J
PROVIDER: S-EPMC6070404 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Chen-Roetling Jing J Regan Kathleen A KA Regan Raymond F RF
Biochemical and biophysical research communications 20180606 1
Hemorrhage into the brain parenchyma or subarachnoid space is associated with edema and vascular injury that is likely mediated at least in part by the toxicity of hemoglobin. In contrast, extravascular blood appears to be less neurotoxic when localized to the retina or adjacent vitreous, the gel filling the posterior segment of the eye. In this study, the hypothesis that vitreous protects neurons from hemoglobin toxicity was investigated in a primary cortical cell culture model. Consistent with ...[more]