Ontology highlight
ABSTRACT:
SUBMITTER: Cholley PE
PROVIDER: S-EPMC6070484 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Cholley Pierre-Etienne PE Moehlin Julien J Rohmer Alexia A Zilliox Vincent V Nicaise Samuel S Gronemeyer Hinrich H Mendoza-Parra Marco Antonio MA
NPJ systems biology and applications 20180802
Complex organisms originate from and are maintained by the information encoded in the genome. A major challenge of systems biology is to develop algorithms that describe the dynamic regulation of genome functions from large omics datasets. Here, we describe TETRAMER, which reconstructs gene-regulatory networks from temporal transcriptome data during cell fate transitions to predict "master" regulators by simulating cascades of temporal transcription-regulatory events. ...[more]