Ontology highlight
ABSTRACT:
SUBMITTER: Kou I
PROVIDER: S-EPMC6070519 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Kou Ikuyo I Watanabe Kota K Takahashi Yohei Y Momozawa Yukihide Y Khanshour Anas A Grauers Anna A Zhou Hang H Liu Gang G Fan Yan-Hui YH Takeda Kazuki K Ogura Yoji Y Zhou Taifeng T Iwasaki Yusuke Y Kubo Michiaki M Wu Zhihong Z Matsumoto Morio M Einarsdottir Elisabet E Kere Juha J Huang Dongsheng D Qiu Guixing G Qiu Yong Y Wise Carol A CA Song You-Qiang YQ Wu Nan N Su Peiqiang P Gerdhem Paul P Ikegawa Shiro S
Scientific reports 20180801 1
Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them is a locus on chromosome 6q24.1 that we identified by a GWAS in a Japanese cohort. The locus is represented by rs6570507 located within GPR126. To ensure the association of rs6570507 with AIS, we conducted a meta-analysis using eight cohorts from East Asia, Norther ...[more]