Ontology highlight
ABSTRACT:
SUBMITTER: Yeo SY
PROVIDER: S-EPMC6070563 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Yeo So-Young SY Lee Keun-Woo KW Shin Dongkwan D An Sugyun S Cho Kwang-Hyun KH Kim Seok-Hyung SH
Nature communications 20180801 1
Although fibroblasts are dormant in normal tissue, they exhibit explosive activation during wound healing and perpetual activation in pathologic fibrosis and cancer stroma. The key regulatory network controlling these fibroblast dynamics is still unknown. Here, we report that Twist1, a key regulator of cancer-associated fibroblasts, directly upregulates Prrx1, which, in turn, increases the expression of Tenascin-C (TNC). TNC also increases Twist1 expression, consequently forming a Twist1-Prrx1-T ...[more]