Ontology highlight
ABSTRACT:
SUBMITTER: Sadato D
PROVIDER: S-EPMC6070656 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Sadato Daichi D Ono Tomio T Gotoh-Saito Saki S Kajiwara Naoki N Nomura Namiko N Ukaji Masako M Yang Liying L Sakimura Kenji K Tajima Youichi Y Oboki Keisuke K Shibasaki Futoshi F
FEBS open bio 20180705 8
Mammalian eukaryotic translation initiation factor 3 (eIF3) is the largest complex of the translation initiation factors. The eIF3 complex is comprised of thirteen subunits, which are named eIF3a to eIF3 m in most multicellular organisms. The <i>eIF3e</i> gene locus is one of the most frequent integration sites of mouse mammary tumor virus (MMTV), which induces mammary tumors in mice. MMTV-integration events result in the expression of C-terminal-truncated eIF3e proteins, leading to mammary tumo ...[more]