Eukaryotic translation initiation factor 3 (eIF3) subunit e is essential for embryonic development and cell proliferation.

ABSTRACT: Mammalian eukaryotic translation initiation factor 3 (eIF3) is the largest complex of the translation initiation factors. The eIF3 complex is comprised of thirteen subunits, which are named eIF3a to eIF3 m in most multicellular organisms. The eIF3e gene locus is one of the most frequent integration sites of mouse mammary tumor virus (MMTV), which induces mammary tumors in mice. MMTV-integration events result in the expression of C-terminal-truncated eIF3e proteins, leading to mammary tumor formation. We have shown that tumor formation can be partly caused by activation of hypoxia-inducible factor 2α. To investigate the function of eIF3e in mammals, we generated eIF3e-deficient mice. These eIF3e^-/- mice are embryonically lethal, while eIF3e^+/-<

SUBMITTER: Sadato D 

PROVIDER: S-EPMC6070656 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature