Ontology highlight
ABSTRACT:
SUBMITTER: Patterson-West J
PROVIDER: S-EPMC6070864 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Patterson-West Jennifer J Arroyo-Mendoza Melissa M Hsieh Meng-Lun ML Harrison Danielle D Walker Morgan M MM Knipling Leslie L Hinton Deborah M DM
Viruses 20180626 7
The lytic bacteriophage T4 employs multiple phage-encoded early proteins to takeover the <i>Escherichia coli</i> host. However, the functions of many of these proteins are not known. In this study, we have characterized the T4 early gene <i>motB</i>, located in a dispensable region of the T4 genome. We show that heterologous production of MotB is highly toxic to <i>E. coli</i>, resulting in cell death or growth arrest depending on the strain and that the presence of <i>motB</i> increases T4 burs ...[more]