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Radiation Pneumonitis: Old Problem, New Tricks.

ABSTRACT: Radiation therapy is a major treatment modality for management of non-small cell lung cancer. Radiation pneumonitis is a dose limiting toxicity of radiotherapy, affecting its therapeutic ratio. This review presents patient and treatment related factors associated with the development of radiation pneumonitis. Research focusing on reducing the incidence of radiation pneumonitis by using information about lung ventilation, imaging-based biomarkers as well as normal tissue complication models is discussed. Recent advances in our understanding of molecular mechanisms underlying lung injury has led to the development of several targeted interventions, which are also explored in this review.

SUBMITTER: Jain V

PROVIDER: S-EPMC6071030 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Radiation Pneumonitis: Old Problem, New Tricks.

Jain Varsha V Berman Abigail T AT

Cancers 20180703 7

Radiation therapy is a major treatment modality for management of non-small cell lung cancer. Radiation pneumonitis is a dose limiting toxicity of radiotherapy, affecting its therapeutic ratio. This review presents patient and treatment related factors associated with the development of radiation pneumonitis. Research focusing on reducing the incidence of radiation pneumonitis by using information about lung ventilation, imaging-based biomarkers as well as normal tissue complication models is di ...[more]

PMID: 29970850

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