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Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy.

ABSTRACT: Microfluidics brings unique opportunities for the synthesis of nanomaterials toward efficient liquid biopsy. Herein, we developed the microreactor-enabled flow synthesis of immunomagnetic nanomaterials with controllable shapes (sphere, cube, rod, and belt) by simply tuning the flow rates. The particle shape-dependent screening efficiency of circulating tumor cells was first investigated and compared with commercial ferrofluids, providing new insights into the rational design of a particulate system toward the screening and analysis of circulating tumor biomarkers.

SUBMITTER: Hao N

PROVIDER: S-EPMC6071334 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy.

Hao Nanjing N Nie Yuan Y Shen Ting T Zhang John X J JXJ

Lab on a chip 20180701 14

Microfluidics brings unique opportunities for the synthesis of nanomaterials toward efficient liquid biopsy. Herein, we developed the microreactor-enabled flow synthesis of immunomagnetic nanomaterials with controllable shapes (sphere, cube, rod, and belt) by simply tuning the flow rates. The particle shape-dependent screening efficiency of circulating tumor cells was first investigated and compared with commercial ferrofluids, providing new insights into the rational design of a particulate sys ...[more]

PMID: 29923569

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