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An amphiphilic pseudo[1]catenane: neutral guest-induced clouding point change.

ABSTRACT: The hydrophobic/hydrophilic ratio in a molecule largely affects its assembled properties in aqueous media. In this study, we synthesized a new bicyclic compound which could dynamically change its hydrophobic/hydrophilic ratio by chemical stimulus. The bicyclic compound consisted of amphiphilic pillar[5]arene and hydrophobic alkyl chain rings, and formed a self-inclusion structure in aqueous media, which was assigned as a pseudo[1]catenane structure. The hydrophobic chain ring was hidden inside the pillar[5]arene cavity in the pseudo[1]catenane structure, thus the bicyclic compound was soluble in water at 20 °C with a clouding point at 24 °C. The pseudo[1]catenane was converted to the de-threaded structure upon addition of the neutral guest 1,4-dicyanobutane, which displaced the alkyl chain ring from the inside to the outside of the cavity. The hydrophobic alkyl chain ring was now exposed to the aqueous media, causing aggregation of the hydrophobic alkyl chain rings, which induced insolubilization of the bicyclic compound in aqueous media at 20 °C and a decrease in its clouding point.

SUBMITTER: Ogoshi T

PROVIDER: S-EPMC6071686 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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An amphiphilic <i>pseudo</i>[1]catenane: neutral guest-induced clouding point change.

Ogoshi Tomoki T Akutsu Tomohiro T Yamagishi Tada-Aki TA

Beilstein journal of organic chemistry 20180726

The hydrophobic/hydrophilic ratio in a molecule largely affects its assembled properties in aqueous media. In this study, we synthesized a new bicyclic compound which could dynamically change its hydrophobic/hydrophilic ratio by chemical stimulus. The bicyclic compound consisted of amphiphilic pillar[5]arene and hydrophobic alkyl chain rings, and formed a self-inclusion structure in aqueous media, which was assigned as a <i>pseudo</i>[1]catenane structure. The hydrophobic chain ring was hidden i ...[more]

PMID: 30112098

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Dataset Information

An amphiphilic pseudo[1]catenane: neutral guest-induced clouding point change.

Publications

An amphiphilic <i>pseudo</i>[1]catenane: neutral guest-induced clouding point change.

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