Ontology highlight
ABSTRACT:
SUBMITTER: Beiroth F
PROVIDER: S-EPMC6071696 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Beiroth Femke F Koudelka Tomas T Overath Thorsten T Knight Stefan D SD Tholey Andreas A Lindhorst Thisbe K TK
Beilstein journal of organic chemistry 20180724
Photoaffinity labeling is frequently employed for the investigation of ligand-receptor interactions in solution. We have employed an interdisciplinary methodology to achieve facile photolabeling of the lectin FimH, which is a bacterial protein, crucial for adhesion, colonization and infection. Following our earlier work, we have here designed and synthesized diazirine-functionalized mannosides as high-affinity FimH ligands and performed an extensive study on photo-crosslinking of the best ligand ...[more]