Ontology highlight
ABSTRACT:
SUBMITTER: Ermakova AM
PROVIDER: S-EPMC6071701 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Ermakova Alina M AM Morozova Julia E JE Shalaeva Yana V YV Syakaev Victor V VV Gubaidullin Aidar T AT Voloshina Alexandra D AD Zobov Vladimir V VV Nizameev Irek R IR Bazanova Olga B OB Antipin Igor S IS Konovalov Alexander I AI
Beilstein journal of nanotechnology 20180727
In order to obtain a non-toxic amphiphilic calixresorcinarene capable to form nanoconjugates for drug encapsulation, tetraundecylcalixresorcinarene functionalized by methoxy poly(ethylene glycol) chains has been synthesized. The macrocycle obtained is characterized by low hemotoxicity. In aqueous solution it forms nanoassociates that are able to encapsulate organic substrates of different hydrophobicity, including drugs (doxorubicin, naproxen, ibuprofen, quercetin). The micelles of the macrocycl ...[more]