Generation of a long-acting fusion inhibitor against HIV-1.
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ABSTRACT:
SUBMITTER: Guo Y
PROVIDER: S-EPMC6071707 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Generation of a long-acting fusion inhibitor against HIV-1.
Guo Ye Y Zhou Pan-Pan PP Zhang Sen-Yan SY Fan Xiao-Wen XW Dou Yu-Wei YW Shi Xuan-Ling XL
MedChemComm 20180606 7
AIDS has evolved from a fatal infectious disease to a manageable chronic disease under the treatment of anti-AIDS medications. HIV fusion inhibitors with high activity, low side effects and strong selectivity are promising drugs against HIV. Only one fusion inhibitor is currently approved, thereby highly active long-acting fusion inhibitors need to be developed for long-term AIDS treatment. Here, we synthesised MT-SC22EK (a small HIV fusion inhibitor) derivatives containing 1-2 staples to improv ...[more]
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