Ontology highlight
ABSTRACT:
SUBMITTER: Luo LX
PROVIDER: S-EPMC6071718 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Luo Lian-Xiang LX Li Ying Y Niu Yu-Zhen YZ Wang Yu-Wei YW Wang Qian-Qian QQ Fan Xing-Xing XX Xu Jia-Hui JH Liu Liang L Leung Elaine Lai-Han EL Yao Xiao-Jun XJ
MedChemComm 20170825 10
ALK-fusion proteins play a fundamental role in the development of about 5% of non-small cell lung cancers. Herein, we identified the compound 5067-0952 as a potent ALK inhibitor, which inhibited cell growth, induced apoptosis, and suppressed the phosphorylation of ALK, subsequently blocking its downstream signaling pathway. ...[more]