Ontology highlight
ABSTRACT:
SUBMITTER: Deng H
PROVIDER: S-EPMC6071720 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
MedChemComm 20170310 5
Inhibitors of diacylglycerol lipases and α,β-hydrolase domain containing protein 6 (ABHD6) are potential leads for the development of therapeutic agents for metabolic and neurodegenerative disorders. Here, we report the enantioselective synthesis and structure activity relationships of triazole ureas featuring chiral, hydroxylated 2-benzylpiperidines as dual inhibitors of DAGLα and ABHD6. The chirality of the carbon bearing the C2 substituent, as well as the position of the hydroxyl (tolerated a ...[more]