Light-responsive CO2 bubble-generating polymeric micelles for tumor cell ablation.
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6071738 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Light-responsive CO<sub>2</sub> bubble-generating polymeric micelles for tumor cell ablation.
Zhang Yifan Y Guan Yuncai Y Ge Sizhan S Yuan Ahu A Wu Jinhui J Wu Jinhui J Hu Yiqiao Y
MedChemComm 20170109 2
We report a novel UV-responsive polymeric micelle system based on coumarin ester for tumor treatment. The micelle itself can generate CO<sub>2</sub> under UV exposure owing to the photolysis of (7-diethylaminocoumarin-4-yl)methyl (DEACM). Without loading any drugs, the micelle causes significant cell death under 8 s UV irradiation <i>in vitro</i>. This is the first time to use light to decompose the nano-carrier itself into CO<sub>2</sub> bubbles for tumor cell ablation. ...[more]
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