Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC6071759 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Liu Yi Y Liang Ren-Ming RM Ma Qing-Ping QP Xu Kai K Liang Xin-Yong XY Huang Wei W Sutton Robert R Ding Jie J O'Neil Paul M PM Cheng Chun-Ru CR
MedChemComm 20170428 6
A series of novel thioether andrographolide derivatives were synthesized by incorporating various aromatic (or heteroaromatic) substituents into C-12 or 14-OH. A total of 38 andrographolide derivatives were prepared and evaluated for their <i>in vitro</i> inhibitory activity against cancer cells. All the derivatives exhibited better activity against prostate cancer cells (PC-3) than the parent compound. Among these, compounds <b>6a</b>, <b>8</b>, <b>9</b>, <b>17</b>, <b>19</b>, <b>31</b>, and <b ...[more]