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Synthesis and DNA/RNA complementation studies of peptide nucleic acids containing 5-halouracils.

ABSTRACT: The monomers of peptide nucleic acids containing 5-halouracils (5-XU-PNA), incorporated into heptameric PNA in the middle position, have been synthesized. Thermodynamic analyses revealed that the heptameric PNA oligomer with DNA and RNA showed higher duplex stability compared to the unmodified PNA counterpart. NMR studies suggested that the electron withdrawing effect of the halogen atom increased the strength of the XU-A hydrogen bond.

SUBMITTER: Liu CD

PROVIDER: S-EPMC6071789 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Synthesis and DNA/RNA complementation studies of peptide nucleic acids containing 5-halouracils.

Liu Chun-Dong CD Wang Jian-Hua JH Xie Yang Y Chen Hang H

MedChemComm 20161212 2

The monomers of peptide nucleic acids containing 5-halouracils (5-XU-PNA), incorporated into heptameric PNA in the middle position, have been synthesized. Thermodynamic analyses revealed that the heptameric PNA oligomer with DNA and RNA showed higher duplex stability compared to the unmodified PNA counterpart. NMR studies suggested that the electron withdrawing effect of the halogen atom increased the strength of the XU-A hydrogen bond. ...[more]

PMID: 30108754

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