Ontology highlight
ABSTRACT:
SUBMITTER: Li ZH
PROVIDER: S-EPMC6071795 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
MedChemComm 20170622 8
A series of thiazolo[5,4-<i>d</i>]pyrimidine derivatives were synthesized and evaluated for their antiproliferative activities against several human cancer cell lines. Structure-activity relationship studies were carried out, showing that most of the target compounds had good inhibition against the tested cell lines. Among them, compound <b>7i</b> exhibited potent inhibition against human gastric cancer cells MGC-803 and HGC-27 with IC<sub>50</sub> values of 4.64 and 5.07 μM, respectively and ar ...[more]