Ontology highlight
ABSTRACT:
SUBMITTER: Yaghootkar H
PROVIDER: S-EPMC6071833 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Yaghootkar Hanieh H Stancáková Alena A Freathy Rachel M RM Vangipurapu Jagadish J Weedon Michael N MN Xie Weijia W Wood Andrew R AR Ferrannini Ele E Mari Andrea A Ring Susan M SM Lawlor Debbie A DA Davey Smith George G Jørgensen Torben T Hansen Torben T Pedersen Oluf O Steinthorsdottir Valgerdur V Guðbjartsson Daniel F DF Thorleifsson Gudmar G Thorsteinsdottir Unnur U Stefansson Kari K Hattersley Andrew T AT Walker Mark M Morris Andrew D AD McCarthy Mark I MI Palmer Colin N A CN Laakso Markku M Frayling Timothy M TM
Diabetes 20150120 6
A recent study identified a low-frequency variant at CCND2 associated with lower risk of type 2 diabetes, enhanced insulin response to a glucose challenge, higher height, and, paradoxically, higher BMI. We aimed to replicate the strength and effect size of these associations in independent samples and to assess the underlying mechanism. We genotyped the variant in 29,956 individuals and tested its association with type 2 diabetes and related traits. The low-frequency allele was associated with a ...[more]