Ontology highlight
ABSTRACT:
SUBMITTER: Duan JR
PROVIDER: S-EPMC6071834 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Duan Jun-Rong JR Liu Han-Bo HB Jeyakkumar Ponmani P Gopala Lavanya L Li Shuo S Geng Rong-Xia RX Zhou Cheng-He CH
MedChemComm 20170216 5
A series of novel Schiff base-bridged tetrahydroprotoberberine (THPB) triazoles were designed, synthesized and characterized for the first time. Antimicrobial assay showed that some of the prepared compounds exerted stronger antibacterial and antifungal activities than the reference drugs. Especially, THPB triazole <b>7a</b> gave low MIC values of 0.5, 1 and 2 μg mL<sup>-1</sup> against <i>B. yeast</i>, <i>M. luteus</i> and MRSA, respectively. Further experiments indicated that the highly active ...[more]