Ontology highlight
ABSTRACT:
SUBMITTER: Liu QH
PROVIDER: S-EPMC6071942 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Liu Qiao-Hong QH Wu Jia-Jia JJ Li Fan F Cai Pei P Yang Xue-Lian XL Kong Ling-Yi LY Wang Xiao-Bing XB
MedChemComm 20170524 7
A series of homoisoflavonoid derivatives was designed, synthesized and evaluated as potential multi-functional anti-Alzheimer's agents for their inhibitory activity on cholinesterase and monoamine oxidase. Among them, compound <b>16</b> showed moderate acetylcholinesterase (AChE) inhibitory activity (eeAChE IC<sub>50</sub> = 0.89 ± 0.02 μM; hAChE IC<sub>50</sub> = 0.657 ± 0.002 μM) and significant monoamine oxidase B (MAO-B) inhibitory activity (hMAO-B IC<sub>50</sub> = 0.0372 ± 0.0002 μM). Kine ...[more]