Ontology highlight
ABSTRACT:
SUBMITTER: Fang A
PROVIDER: S-EPMC6072013 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
MedChemComm 20170707 8
Human lactate dehydrogenase A (LDHA) has been identified as a potential therapeutic target in the area of cancer metabolism. Herein, we report the discovery of novel LDHA inhibitors through docking-based virtual screening and biological assays. The primary enzymatic assay suggested that compound <b>11</b> targeted LDHA with an IC<sub>50</sub> value of 0.33 μM. The <i>in vitro</i> cytotoxic assay demonstrated that compound <b>11</b> reduced the growth of MG-63 cancer cells with an EC<sub>50</sub> ...[more]