Studies towards elucidating the potential of 5,10,15,20-tetrakis(p-carboxy-methyleneoxyphenyl)porphyrin as a theranostic agent for applications in PET and PDT.

ABSTRACT: Porphyrins, owing to their inherent tendency to accumulate in tumorous lesions, are considered suitable for developing agents for theranostic applications involving tumor diagnosis and targeted tumor therapy. The aim of the present work is to study the potential of a porphyrin derivative namely, 5,10,15,20-tetrakis(p-carboxymethyleneoxyphenyl)porphyrin (SPTA) as a theranostic agent for applications in positron emission tomography (PET) and photodynamic therapy (PDT). SPTA was synthesized in-house following a three-step reaction process and characterized by using spectroscopic techniques, viz. UV-vis, FT-IR, ¹H-NMR and ¹³C-NMR spectroscopy, as well as by mass spectrometry. SPTA was labeled with ⁶⁸Ga, a generator produced PET radioisotope, and t

SUBMITTER: Guleria M 

PROVIDER: S-EPMC6072032 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature