Transcriptional analysis of viral mRNAs reveals common transcription patterns in cells infected by five different filoviruses.

ABSTRACT: Filoviruses are notorious viral pathogens responsible for high-consequence diseases in humans and non-human primates. Transcription of filovirus mRNA shares several common features with transcription in other non-segmented negative-strand viruses, including differential expression of genes located across the viral genome. Transcriptional patterns of Ebola virus (EBOV) and Marburg virus (MARV) have been previously described using traditional, laborious methods, such as northern blots and in vivo labeling of viral mRNAs. More recently, however, the availability of the next generation sequencing (NGS) technology has offered a more straightforward approach to assess transcriptional patterns. In this report, we analyzed the transcription patterns of four ebolaviruses-EBOV, Sudan (SUDV), Bundibu

SUBMITTER: Albarino CG 

PROVIDER: S-EPMC6072132 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature