Ontology highlight
ABSTRACT:
SUBMITTER: Sayeed IB
PROVIDER: S-EPMC6072242 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
MedChemComm 20170306 5
A library of imidazopyridine-propenone conjugates (<b>8a-8u</b>) were synthesized and evaluated for their antitumor activity against four human cancer cell lines, namely, prostate (DU-145), lung (A549), cervical (Hela) and breast (MCF-7) cancer cell lines. These conjugates showed good to moderate activity against the tested cell lines. Among them, two conjugates (<b>8m</b> and <b>8q</b>) showed significant antiproliferative activity against the human lung cancer cell line (A549) with IC<sub>50</ ...[more]