Dataset Information

Antibacterial and Photocatalytic Properties of ZnO-9-Aminoacridine Hydrochloride Hydrate Drug Nanoconjugates.

ABSTRACT: The development of nanomaterial-based hybrid systems for healthcare and energy-related materials has attracted significant attention nowadays. Here, we have designed a nanocomposite of ZnO nanoparticles (NPs) with anticancer therapeutic drug 9-aminoacridine hydrochloride hydrate (9AA-HCl) for antibacterial and photocatalytic activities. Spectroscopic studies reveal that the photoinduced electron transfer from photoexcited 9AA-HCl to the conduction band of ZnO NP causes the generation of the reactive oxygen species (ROS), which is responsible for antibacterial activity and photocatalytic properties. It is seen that the efficiency of photodegradation of dye molecules increases in ZnO-9AA-HCl nanoconjugated systems than pure ZnO nanoparticles because of efficient charge separation. In addition, the antibacterial efficacy of the nanoconjugate is investigated using a strain of Gram-negative bacteria where the cell-killing activities are observed 99.99 and 100% for 20 and 21 ?L/mL nanoconjugate, respectively, and very little cell-killing activity is observed for free ZnO NPs and free drug. Moreover, it is also observed that the nanoconjugate generates sufficient intracellular ROS that can hydrolyze 2',7'-dichlorodihydrofluoresceindiacetate (DCFH-DA) to highly fluorescent 2',7'-dichlorofluorescein (DCF). The outcome of the study will provide valuable information for designing new-edge nanoconjugate materials for potential applications in photocatalytic and antibacterial activities.

SUBMITTER: Mitra P

PROVIDER: S-EPMC6072247 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Antibacterial and Photocatalytic Properties of ZnO-9-Aminoacridine Hydrochloride Hydrate Drug Nanoconjugates.

Mitra Piyali P Dutta Debanjan D Das Somnath S Basu Tarakdas T Pramanik Amitava A Patra Amitava A

ACS omega 20180717 7

The development of nanomaterial-based hybrid systems for healthcare and energy-related materials has attracted significant attention nowadays. Here, we have designed a nanocomposite of ZnO nanoparticles (NPs) with anticancer therapeutic drug 9-aminoacridine hydrochloride hydrate (9AA-HCl) for antibacterial and photocatalytic activities. Spectroscopic studies reveal that the photoinduced electron transfer from photoexcited 9AA-HCl to the conduction band of ZnO NP causes the generation of the reac ...[more]

PMID: 30087929

Similar Datasets

Project description:In this article, ZnO:NiO:CuO nanocomposites (NCPs) were synthesized using a hydrothermal method, with different Zn : Ni : Cu molar ratios (1 : 1 : 1, 2 : 1 : 1, 1 : 2 : 1, and 1 : 1 : 1). The PXRD confirmed the formation of a NCP consisting of ZnO (hexagonal), NiO (cubic), and CuO (monoclinic) structures. The crystallite sizes of NCPs were calculated using Debye Scherrer and Williamson-Hall methods. The calculated crystalline sizes (Scherrer method) of the NCPs were determined to be 21, 27, 23, and 20 nm for the molar ratios 1 : 1 : 1, 2 : 1 : 1, 1 : 2 : 1, and 1 : 1 : 2, respectively. FTIR spectra confirmed the successful formation of heterojunction NCPs via the presence of metal-oxygen bonds. The UV-vis spectroscopy was used to calculate the bandgap of synthesized samples and was found in the range of 2.99-2.17 eV. SEM images showed the mixed morphology of NCPs i.e., irregular spherical and rod-like structures. The dielectric properties, including AC conductivity, dielectric constant, impedance, and dielectric loss parameters were measured using an LCR meter. The DC electrical measurements revealed that NCPs have a high electrical conductivity. All the NCPs were evaluated for the photocatalytic degradation of Methylene blue (MB), methyl orange (MO), and a mixture of both of these dyes. The NCPs with a molar ratio 1 : 1 : 2 (Zn : Ni : Cu) displayed outstanding photocatalytic activity under sunlight, achieving the degradation efficiency of 98% for methylene blue (MB), 92% for methyl orange (MO) and more than 87% in the case of a mixture of dyes within just 90 minutes of illumination. The antibacterial activity results showed the more noxious nature of NCPs against Gram-negative bacteria with a maximum zone of inhibition revealed by the NCPs of molar ratio 1 : 2 : 1 (Zn : Ni : Cu). On the basis of these observations, it can be anticipated that the NCPs can be successfully employed for the purification of contaminated water by the degradation of hazardous organic compounds and in antibacterial ointments.

Dataset Information

Antibacterial and Photocatalytic Properties of ZnO-9-Aminoacridine Hydrochloride Hydrate Drug Nanoconjugates.

Publications

Antibacterial and Photocatalytic Properties of ZnO-9-Aminoacridine Hydrochloride Hydrate Drug Nanoconjugates.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets