Administration of a Nucleoside Analog Promotes Cancer Cell Death in a Telomerase-Dependent Manner.
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ABSTRACT:
SUBMITTER: Zeng X
PROVIDER: S-EPMC6072277 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Administration of a Nucleoside Analog Promotes Cancer Cell Death in a Telomerase-Dependent Manner.
Zeng Xuehuo X Hernandez-Sanchez Wilnelly W Xu Mengyuan M Whited Tawna L TL Baus Diane D Zhang Junran J Berdis Anthony J AJ Taylor Derek J DJ
Cell reports 20180601 10
Telomerase, the end-replication enzyme, is reactivated in malignant cancers to drive cellular immortality. While this distinction makes telomerase an attractive target for anti-cancer therapies, most approaches for inhibiting its activity have been clinically ineffective. As opposed to inhibiting telomerase, we use its activity to selectively promote cytotoxicity in cancer cells. We show that several nucleotide analogs, including 5-fluoro-2'-deoxyuridine (5-FdU) triphosphate, are effectively inc ...[more]
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