Ontology highlight
ABSTRACT:
SUBMITTER: Kucwaj-Brysz K
PROVIDER: S-EPMC6072329 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Kucwaj-Brysz Katarzyna K Kurczab Rafał R Żesławska Ewa E Lubelska Annamaria A Marć Małgorzata Anna MA Latacz Gniewomir G Satała Grzegorz G Nitek Wojciech W Kieć-Kononowicz Katarzyna K Handzlik Jadwiga J
MedChemComm 20180508 6
In order to search for active and selective serotonin 5-HT<sub>7</sub>R antagonists among 3,5-disubstituted arylpiperazine-imidazolidine-2,4-diones, the role of the introduction/deletion and the mutual orientation of aromatic rings was analyzed. Chemical modifications of 2nd generation lead structure of 3-(3-(4-(diphenylmethyl)piperazin-1-yl)-2-hydroxypropyl)-5-(4-fluorophenyl)-5-methylimidazolidine-2,4-dione (<b>2</b>, KKB16) were performed. New derivatives (<b>4-18</b>) were designed and synth ...[more]