Ontology highlight
ABSTRACT:
SUBMITTER: Consoli GML
PROVIDER: S-EPMC6072334 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
MedChemComm 20171201 1
The growing antibiotic resistance phenomenon continues to stimulate the search for new compounds and strategies to combat bacterial infections. In this study, we designed and synthesized a new polycationic macrocyclic compound (<b>2</b>) bearing four <i>N</i>-methyldiethanol ammonium groups clustered and circularly organized by a calix[4]arene scaffold. The <i>in vitro</i> activity of compound <b>2</b>, alone and in combination with known antibiotics (ofloxacin, chloramphenicol or tetracycline), ...[more]