Ontology highlight
ABSTRACT:
SUBMITTER: Lan JS
PROVIDER: S-EPMC6072412 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Lan Jin-Shuai JS Zhang Tong T Liu Yun Y Zhang Yong Y Hou Jian-Wei JW Xie Sai-Sai SS Yang Jing J Ding Yue Y Cai Zhen-Zhen ZZ
MedChemComm 20170105 2
A new series of small molecules bearing a benzyloxy substituent have been designed, synthesized and evaluated for hMAO inhibitory activity <i>in vitro</i>. Most of the compounds were potent and selective MAO-B inhibitors, and were weak inhibitors of MAO-A. In particular, compounds <b>9e</b> (IC<sub>50</sub> = 0.35 μM) and <b>10e</b> (IC<sub>50</sub> = 0.19 μM) were the most potent MAO-B inhibitors, and exhibited the highest selectivity for MAO-B (<b>9e</b>, SI > 285.7-fold and <b>10e</b>, SI = 1 ...[more]