Dataset Information

Saponin from sea cucumber exhibited more significant effects than ginsenoside on ameliorating high fat diet-induced obesity in C57BL/6 mice.

ABSTRACT: Obesity and its comorbidities are considered to be a severe public health problem. Many natural compounds found in food have been proved to ameliorate the metabolic abnormalities induced by obesity. The purpose of this study was to compare the effects of saponin from sea cucumber (SSC) and ginsenoside (SG) on improving the lipid metabolism in C57BL/6 mice fed with a high fat diet. The mice were randomly divided into six groups including a low fat diet group (LF), a high fat diet group (HF), and four dietary intervention groups. The administration of SSC for 8 weeks exhibited a more significant reduction in HF induced fat mass, weight gain, lipid levels in the liver and serum, and serum glucose and insulin levels than SG. Further research indicated that SSC ameliorated high fat diet-induced obesity in C57BL/6 mice mainly through inhibiting lipid synthesis and accelerating lipid ?-oxidation and glycolysis in the liver. These results suggested that saponin from sea cucumber might be applied as a food supplement and/or functional ingredient to relieve metabolic disorders induced by obesity.

SUBMITTER: Meng J

PROVIDER: S-EPMC6072430 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Saponin from sea cucumber exhibited more significant effects than ginsenoside on ameliorating high fat diet-induced obesity in C57BL/6 mice.

Meng Jing J Hu Xiaoqian X Zhang Tiantian T Dong Ping P Li Zhaojie Z Xue Changhu C Chang Yaoguang Y Wang Yuming Y

MedChemComm 20180320 4

Obesity and its comorbidities are considered to be a severe public health problem. Many natural compounds found in food have been proved to ameliorate the metabolic abnormalities induced by obesity. The purpose of this study was to compare the effects of saponin from sea cucumber (SSC) and ginsenoside (SG) on improving the lipid metabolism in C57BL/6 mice fed with a high fat diet. The mice were randomly divided into six groups including a low fat diet group (LF), a high fat diet group (HF), and ...[more]

PMID: 30108963

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Project description:Cancer remains the leading cause of death worldwide. In spite of significant advances in targeted and immunotherapeutic approaches, clinical outcomes for cancer remain poor. The aim of the present study was to investigate the potential mechanisms and therapeutic targets of Frondoside A for the treatment of liver, pancreatic, and bladder cancers. The data presented in our study demonstrated that Frondoside A reduced the viability and migration of HepG2, Panc02, and UM-UC-3 cancer cell in vitro. Moreover, we utilized the GEO database to screen and identify for differentially expressed genes (DEGs) in liver, pancreatic, and bladder cancers, which resulted in the identification of 714, 357, and 101 DEGs, respectively. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation were performed using the Metascape database for DEGs that were significantly associated with cancer development. The protein-protein interaction (PPI) networks of the identified DEGs in liver, pancreatic, and bladder cancers were analyzed using Cytoscape 3.9.0 software, and subsequently identified potential key genes that were associated with these networks. Subsequently, their prognostic values were assessed by gene expression level analysis and Kaplan-Meier survival analysis (GEPIA). Furthermore, we utilized TIMER 2.0 to investigate the correlation between the expression of the identified key gene and cancer immune infiltration. Finally, molecular docking simulations were performed to assess the affinity of Frondoside A and key genes. Our results showed a significant correlation between these DEGs and cancer progression. Combined, these analyses revealed that Frondoside A involves in the regulation of multiple pathways, such as drug metabolism, cell cycle in liver cancer by inhibiting the expression of CDK1, TOP2A, CDC20, and KIF20A, and regulates protein digestion and absorption, receptor interaction in pancreatic cancer by down-regulation of ASPM, TOP2A, DLGAP5, TPX2, KIF23, MELK, LAMA3, and ANLN. While in bladder cancer, Frondoside A regulates muscle contraction, complement and coagulation cascade by increase FLNC expression. In conclusion, the present study offers valuable insights into the molecular mechanism underlying the anticancer effects of Frondoside A, and suggests that Frondoside A can be used as a functional food supplement or further developed as a natural anti-cancer drug.

Dataset Information

Saponin from sea cucumber exhibited more significant effects than ginsenoside on ameliorating high fat diet-induced obesity in C57BL/6 mice.

Publications

Saponin from sea cucumber exhibited more significant effects than ginsenoside on ameliorating high fat diet-induced obesity in C57BL/6 mice.

Similar Datasets

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