Ontology highlight
ABSTRACT:
SUBMITTER: Luo J
PROVIDER: S-EPMC6072463 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Luo Junjie J Hu Zhiye Z Xiao Yuan Y Yang Tongxin T Dong Chune C Huang Jian J Zhou Hai-Bing HB
MedChemComm 20170524 7
To increase the diversity of estrogen receptor (ER) ligands having novel structures and activities, series of selenophene derivatives with a basic side chain (BSC) were synthesized and their biological activity as subtype-selective antagonists for the ER was explored. Compared with the selenophenes without a BSC, most compounds showed an increase in binding affinity, and several compounds displayed enhanced antagonist potency and antiproliferative activity. Especially, compound <b>16c</b> exhibi ...[more]