Ontology highlight
ABSTRACT:
SUBMITTER: Danne AB
PROVIDER: S-EPMC6072531 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Danne Ashruba B AB Choudhari Amit S AS Chakraborty Shakti S Sarkar Dhiman D Khedkar Vijay M VM Shingate Bapurao B BB
MedChemComm 20180411 7
We describe the synthesis of novel triazole-incorporated diindolylmethanes (DIMs) using a molecular hybridization approach. The <i>in vitro</i> antitubercular activity of the DIMs against <i>Mycobacterium tuberculosis</i> H37Ra (ATCC 25177) was tested in the active and dormant state. Among all the synthesized conjugates, the compounds <b>6b</b>, <b>6f</b>, <b>6l</b>, <b>6n</b>, <b>6q</b>, <b>6r</b>, and <b>6s</b> displayed good antitubercular activity against both the active and dormant <i>Mtb</ ...[more]