Ontology highlight
ABSTRACT:
SUBMITTER: Li G
PROVIDER: S-EPMC6072570 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature genetics 20180716 8
Genome-wide association studies (GWAS) have identified many disease-associated noncoding variants, but cannot distinguish functional single-nucleotide polymorphisms (fSNPs) from others that reside incidentally within risk loci. To address this challenge, we developed an unbiased high-throughput screen that employs type IIS enzymatic restriction to identify fSNPs that allelically modulate the binding of regulatory proteins. We coupled this approach, termed SNP-seq, with flanking restriction enhan ...[more]