Ontology highlight
ABSTRACT:
SUBMITTER: Shim HG
PROVIDER: S-EPMC6072779 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Shim Hyun Geun HG Jang Sung-Soo SS Kim Seung Ha SH Hwang Eun Mi EM Min Joo Ok JO Kim Hye Yun HY Kim Yoo Sung YS Ryu Changhyeon C Chung Geehoon G Kim YoungSoo Y Yoon Bo-Eun BE Kim Sang Jeong SJ
Scientific reports 20180802 1
For decades, the glial function has been highlighted not only as the 'structural glue', but also as an 'active participant' in neural circuits. Here, we suggest that tumor necrosis factor α (TNF-α), a key inflammatory cytokine, alters the neural activity of the cerebellar Purkinje cells (PCs) by facilitating gliotransmission in the juvenile male rat cerebellum. A bath application of TNF-α (100 ng/ml) in acute cerebellar slices elevates spiking activity of PCs with no alterations in the regularit ...[more]