Ontology highlight
ABSTRACT:
SUBMITTER: Blache U
PROVIDER: S-EPMC6073216 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
EMBO reports 20180702 8
The fate of mesenchymal stem cells (MSCs) in the perivascular niche, as well as factors controlling their fate, is poorly understood. Here, we study MSCs in the perivascular microenvironment of endothelial capillaries by modifying a synthetic 3D biomimetic poly(ethylene glycol) (PEG)-hydrogel system <i>in vitro</i> We show that MSCs together with endothelial cells form micro-capillary networks specifically in soft PEG hydrogels. Transcriptome analysis of human MSCs isolated from engineered capil ...[more]