Ontology highlight
ABSTRACT:
SUBMITTER: Fujita K
PROVIDER: S-EPMC6073286 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Fujita Koji K Mimura Shima S Iwama Hisakazu H Nakahara Mai M Oura Kyoko K Tadokoro Tomoko T Nomura Takako T Tani Joji J Yoneyama Hirohito H Morishita Asahiro A Oryu Makoto M Himoto Takashi T Nishitsuji Hironori H Shimotohno Kunitada K Omata Masao M Masaki Tsutomu T
International journal of molecular sciences 20180702 7
The therapeutic goal for hepatitis B virus (HBV) infection is HBs antigen (HBsAg) seroclearance, which is achieved through 48-week pegylated interferon (Peg-IFN) therapy. This study aimed to identify predictive biomarkers for sustained HBsAg reduction by analyzing serum microRNAs. Twenty-two consecutive chronic HBV infection patients negative for HBe antigen (HBeAg) with HBV-DNA levels <5 log copies/mL, alanine aminotransferase (ALT) <100 U/L, and compensated liver functions, were enrolled. The ...[more]