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Non-Coding RNAs in Endometrial Physiopathology.

ABSTRACT: The Human Genome Project led to the discovery that about 80% of our DNA is transcribed in RNA molecules. Only 2% of the human genome is translated into proteins, the rest mostly produces molecules called non-coding RNAs, which are a heterogeneous class of RNAs involved in different steps of gene regulation. They have been classified, according to their length, into small non-coding RNAs and long non-coding RNAs, or to their function, into housekeeping non-coding RNAs and regulatory non-coding RNAs. Their involvement has been widely demonstrated in all cellular processes, as well as their dysregulation in human pathologies. In this review, we discuss the function of non-coding RNAs in endometrial physiology, analysing their involvement in embryo implantation. Moreover, we explore their role in endometrial pathologies such as endometrial cancer, endometriosis and chronic endometritis.

SUBMITTER: Ferlita A

PROVIDER: S-EPMC6073439 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Non-Coding RNAs in Endometrial Physiopathology.

Ferlita Alessandro La A Battaglia Rosalia R Andronico Francesca F Caruso Salvatore S Cianci Antonio A Purrello Michele M Pietro Cinzia Di CD

International journal of molecular sciences 20180720 7

The Human Genome Project led to the discovery that about 80% of our DNA is transcribed in RNA molecules. Only 2% of the human genome is translated into proteins, the rest mostly produces molecules called non-coding RNAs, which are a heterogeneous class of RNAs involved in different steps of gene regulation. They have been classified, according to their length, into small non-coding RNAs and long non-coding RNAs, or to their function, into housekeeping non-coding RNAs and regulatory non-coding RN ...[more]

PMID: 30037059

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