Role of the vacuolar ATPase in the Alphavirus replication cycle.
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ABSTRACT:
SUBMITTER: Schuchman RM
PROVIDER: S-EPMC6074608 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Role of the vacuolar ATPase in the <i>Alphavirus</i> replication cycle.
Schuchman Ryan M RM Vancini Ricardo R Piper Amanda A Breuer Denitra D Ribeiro Mariana M Ferreira Davis D Magliocca Joseph J Emmerich Veronica V Hernandez Raquel R Brown Dennis T DT
Heliyon 20180725 7
We have shown that <i>Alphaviruses</i> can enter cells by direct penetration at the plasma membrane (R. Vancini, G. Wang, D. Ferreira, R. Hernandez, and D. Brown, J Virol, 87:4352-4359, 2013). Direct penetration removes the requirement for receptor-mediated endocytosis exposure to low pH and membrane fusion in the process of RNA entry. Endosomal pH as well as the pH of the cell cytoplasm is maintained by the activity of the vacuolar ATPase (V-ATPase). Bafilomycin is a specific inhibitor of V-ATP ...[more]
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